منابع مشابه
Gut and adipocyte peptides.
Glucagon-like peptide-1 (and related hormones) Daniel Drucker (Toronto, Canada) reviewed evidence that the incretin effect, the phenomenon of enteral glucose loading increasing the insulin secretory response to an increase in blood glucose, is reduced in type 2 diabetes, and that the incretin glucagon-like peptide (GLP)-1 may ameliorate this defect. The major limitation to use of GLP-1 in clini...
متن کاملBrain and gut peptides.
The first evidence that the same peptides could be present in both the brain and the gut was given in 1931 with the discovery of substance P (Von Euler and Gaddum, 1931). In spite of this early start, the important revelation that there were a large number of peptides with this dual localisation and also with powerful and extensive pharmacological actions took more than 40 years to materialise....
متن کاملGut adaptation and the glucagon-like peptides.
The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 ma...
متن کاملMolecular aspects of restitution: functions of trefoil peptides.
Healing of mucosal damage takes place in two phases: restitution of mucosal integrity and remodeling towards recreating the original glandular arrangements. These processes can be observed in several experimental rodent models: e.g., cryoprobe or NSAID-generated ulcers in the gastric or duodenal mucosa and following surgical resection of the small or large bowel. In some studies, it has been po...
متن کاملMinireview: Gut peptides regulating satiety.
The gastrointestinal tract and the pancreas release hormones regulating satiety and body weight. Ghrelin stimulates appetite, and glucagon-like peptide-1, oxyntomodulin, peptide YY, cholecystokinin, and pancreatic polypeptide inhibit appetite. These gut hormones act to markedly alter food intake in humans and rodents. Obesity is the current major cause of premature death in the United Kingdom, ...
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ژورنال
عنوان ژورنال: Gut
سال: 1993
ISSN: 0017-5749
DOI: 10.1136/gut.34.5.577